120:360
Biochemistry
Fall 2009
Instructor: Dr. Gerald Frenkel
Office: 321 Boyden
Tel: 5071
E-mail: frenkel@andromeda.rutgers.edu
Class time and place: MTh 8:30-9:50; Room 103 Hill Hall
Course Website: http://newarkbioweb.rutgers.edu/bio360
Course prerequisites: General Biology, Foundations in Biology, General Chemistry, Organic Chemistry
Course objective: To gain a deeper understanding of cell function by a study of the structure, function, and metabolism of its component molecules.
Required Text: Voet, Voet & Pratt, Fundamentals of Biochemistry (Wiley) [either 2nd Edition (2006) (ISBN # 9780471214953) or 3rd Edition (2008) (ISBN # 978-0470129302 or 978-0470279892]
Other Resources:
Easier:
Campbell, Biochemistry
Horton et al, Principles of Biochemistry
More advanced:
Voet & Voet Biochemistry
Garrett & Grisham, Biochemistry
http://themedicalbiochemistrypage.org
http://www.bio.cmu.edu/Courses/BiochemMols/BCMolecules.html
Lecture Schedule
[Changes made after 9/3/09 will be shown in red]
Note: Follow the links below to more information on the topic. To use the molecular modeling feature you will need the plug-in Chime (click to download).
Date |
Topic |
Readings in Voet 2nd Edition |
Readings in Voet 3rd Edition |
| Preparatory reading | 12-19; Ch. 2 | 11-19; Ch. 2 | |
| 9/3 | Amino acids | Ch. 4 | Ch. 4 |
| 9/8 | Proteins I | 95-108 | 91-103 |
| 9/10 | Proteins II | 130-144 | 125-140 |
| 9/14 | Proteins III | 149-161; 170-174;182-185 | 146-150; 156-160; 168-172;177-180 |
| 9/17 | Proteins IV | 185-204 | 181-197 |
| 9/21 | Lipids | 234-242 | 246-253 |
| 9/24 | Cholesterol and lipoproteins | 242-245; 248-251; 628-635 | 254-256; 260-263; 678-685 |
| 9/28 | NO CLASS | ||
| 10/1 | Carbohydrates | 207-222 | 220-231 |
| 10/5 | Lecture Exam 1 | ||
| 10/8 | Enzymes I | 313-318; 358-368 | 322-327; 364-375 |
| 10/12 | Enzymes II | 369-377 | 375-383 |
| 10/15 | Enzymes III | 380-385; 319-321 | 386-390; 328-330 |
| 10/19 | Enzymes IV | 340-350 | 347-357 |
| 10/22 | Introduction to metabolism & bioenergetics | 396-415 | 451-470 |
| 10/26 | Glycolysis & fermentation I | 428-446; 452-456 | 486-504; 510-514 |
| 10/29 | Glycolysis & fermentation II Glycogen breakdown |
446-451
473-479; 489-493 |
504-510 532-536; 545-546 |
| 11/2 | Pyruvate dehydrogenase | 519-524; 533 | 570-576; 585 |
| 11/5 | Lecture Exam 2 | ||
| 11/9 | Citric acid cycle | 515-517; 525-531 | 567-570; 576-583 |
| 11/12 | Fatty acid catabolism | 635-640; 649-650 | 685-690; 698-700 |
| 11/16 | Amino acid catabolism | 688-697 | 738-747 |
| 11/19 | Oxidation/reduction reactions Electron transport |
414-419; 549-567 | 469-474; 600-618 |
| 11/23 | 567-579 | 618-631 | |
| 11/30 | Carbohydrate biosynthesis | 500-507; 481-486; 489-500 | 552-559; 540-542; 545(Section B)-552 |
| 12/3 | Fatty acid biosynthesis | 650-657; 462-463 | 701-707; 520-521 |
| 12/7 | Nucleotide biosynthesis | 41-43; 790; 793; 796; 798-799 | 40-42; 819; 821-822; 825-827 |
| 12/10 | Lecture Exam 3 | ||
| 12/17 (8:30-11:30) |
Final Exam |
Grades
The course grade will be calculated as follows:
There will be 3 lecture exams, each covering approximately one third of the course. These exams will be multiple-choice. The lowest grade of the three will be dropped, and each of the remaining two will be worth 35% of the course grade. In addition there will be a comprehensive final exam (covering the entire course) that will be worth 30% of the course grade.
Please note: All exam grades will be posted on Blackboard. In order to access Blackboard you need a Rutgers NetID.
Makeup exams
A make-up examination will be available for students who must miss a regularly scheduled exam for an officially approved reason (see university guidelines). Please notify the instructor as soon as possible prior to the scheduled exam.